Carbon dioxide negatively modulates N -methyl- d -aspartate receptors
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چکیده
منابع مشابه
Carbon dioxide negatively modulates N-methyl-D-aspartate receptors.
BACKGROUND Carbon dioxide (CO2) dose-dependently decreases minimum alveolar concentration (MAC) of anaesthetics in rats. CO2 also dose-dependently decreases cerebrospinal fluid pH. N-methyl-D-aspartate (NMDA) channels exhibit pH sensitivity and are putative targets for inhaled anaesthetics. We hypothesized that CO2 dose-dependently decreases rat NMDA channel current via an acidifying effect at ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2008
ISSN: 0007-0912
DOI: 10.1093/bja/aen266